Microstructure & Connectivity Lab
Research
Microstructure & Connectivity Lab
Research
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Research
Research in Microstructure & Connectivity Lab
Research in Microstructure & Connectivity Lab
Welcome to our research lab focused on advancing imaging methods to better understand the microstructure and structural connectivity of the brain and spinal cord. Under the direction of Dr. Kurt Schilling, our team of researchers at Vanderbilt University Medical Center specializes in neuroanatomy, image acquisition and processing, and bioinformatics across large multimodal datasets. By developing and validating new techniques to map neural pathways and quantify tissue microstructure, we aim to bridge insights from fundamental neuroscience to clinical applications, ultimately improving care for individuals with neurological disorders.
Below are five key areas of investigation:
1. In Vivo Virtual Dissection of the Brain
1. In Vivo Virtual Dissection of the Brain
We employ diffusion MRI tractography as a powerful, non-invasive way to visualize and analyze white matter pathways in the living brain. Our work refines and validates these techniques, ensuring accurate representations of the brain’s intricate wiring. This foundational research helps us identify biomarkers for neurological conditions, refine clinical imaging protocols, and deepen our overall understanding of neural connectivity.
2. Mapping Microstructure of the Central Nervous System
2. Mapping Microstructure of the Central Nervous System
Our lab develops and evaluates methods for quantifying tissue microstructure—from axon diameters to cellular organization—across the brain and spinal cord. By comparing MRI outputs with histological measurements, we continually refine MRI acquisition and processing, bringing us closer to a true in vivo virtual histology that aids both research and clinical evaluations.
3. Charting White Matter Structure and Function Across the Lifespan
3. Charting White Matter Structure and Function Across the Lifespan
We integrate longitudinal diffusion MRI measures with advanced modeling to investigate how white matter evolves from childhood through older adulthood. These studies clarify how neural pathways develop, change, and potentially deteriorate, revealing critical markers for cognitive decline, neurodevelopment, and neurodegenerative diseases.
4. Enabling Reproducible Research Through Open-Sourced Tools and Databases
4. Enabling Reproducible Research Through Open-Sourced Tools and Databases
To uphold rigor and reproducibility in imaging research, we create open-source pipelines, quality assurance protocols, and datasets. We also organize international challenges that evaluate and compare state-of-the-art methods for brain mapping and microstructural modeling. By sharing these resources, we empower the broader community to optimize imaging protocols, ensure data integrity, and foster collaborative innovation.
5. Image Acquisition and Processing Methods for the Spinal Cord
5. Image Acquisition and Processing Methods for the Spinal Cord
Our expertise extends to spinal cord imaging, where we address unique challenges like motion, distortion, and signal variability. By developing cutting-edge diffusion MRI techniques, we establish normative metrics and identify biomarkers for conditions such as Multiple Sclerosis, paving the way for earlier detection and more targeted clinical interventions.
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