Microstructure & Connectivity Lab
Resources
Resources
We've shared (1) Code + Processes, (2) Datasets (3) Lectures + Seminars, and (4) Lab News to help inform your own research
Synb0-DISCO: This tool aims to enable susceptibility distortion correction with historical and/or limited datasets that do not include specific sequences for distortion correction (i.e. reverse phase-encoded scans)
PreQual integrated preprocessing and quality assurance of diffusion MRI data.
CoRNN Tractography Tractography on T1-weighted MRI, no diffusion needed!
Description: Population-based collection of white matter atlases represented in both volumetric and surface coordinates in a standard space. These atlases are based on 2443 subjects, and include 216 white matter bundles derived from 6 different automated state-of-the-art tractography techniques. Hansen et al., NeuroInformatics, 2021
The VALiDATe29 squirrel monkey brain atlas was created from MRI scans of 29 squirrel monkey brains. The atlas is currently comprised of multiple anatomical templates (proton density, T1, T2* weighted), diffusion MRI templates (fractional anisotropy, mean diffusivity), and ex vivo templates (fractional anisotropy and a structural MRI). In addition, the templates are combined with histologically defined cortical labels, and diffusion tractography defined white matter labels. Schilling et al., NeuroInformatics, 2017
MASiVar is a dataset consisting of 319 diffusion scans acquired at 3T from b = 1000 to 3000 s/mm2 across 14 healthy adults, 83 healthy children (5 to 8 years), three sites, and four scanners curated to promote investigation of diffusion MRI variability. Cohort I consists of one adult subject scanned repeatedly on one scanner. This subject underwent three separate imaging sessions and acquired 3-4 scans per session. Cohort II consists of 5 adult subjects each scanned on 3-4 different scanners across 3 institutions. Each subject underwent 1-2 sessions on each scanner and had one scan acquired per session. Cohort III consists of 8 adult subjects all scanned on one scanner. Each subject underwent 1-6 sessions on the scanner and had two scans acquired per session. Cohort IV consists of 83 child subjects all scanned on one scanner. Each subject underwent 1-2 sessions on the scanner and had two scans acquired per session. Cai et al., Magn Reson Med, 2021
We characterized the prevalence of bottleneck regions, or where multiple white matter pathways of the brain converge and subsequently diverge. These are areas of the brain that present challenges for diffusion tractography, yet represent information highways where dense bundles flow together. Here, we make available bottleneck maps of the brain in a standard space, and provide a map of these junction areas to be used in future studies of the brain. Schilling et al., Human Brain Mapping, 2021
Six sets of images sensitive to BOLD contrast (TR=3s, TE=45ms, SENSE=2, matrix=80×80, FOV=240×240mm2, 3 mm thick slice with zero gap, 145 volumes). The BOLD images contained a resting state acquisition (Resting), sensory stimulations to the right hand and the left hand (Sensory-R and Sensory-L), motor tasks by the subjects’ right hand and left hand (Motor-R and Motor-L), and visual stimulations (Visual) | All stimulations/tasks were prescribed in a block design format (30s on, 30s off), with five additional volumes acquired without stimulations or tasks at the beginning of each run | The blocks of stimulation or task were repeated seven times for each of the functional acquisitions. The total acquisition time was 435s, yielding 145 volumes for each task/stimulation | MRI acquired on a 3-T Philips Achieva CRX scanner at Vanderbilt University Institute of Imaging Science. Schilling et al., PNAS, 2023
Abstract: The talk presents a historical review of 'streamlines' covering the early days of dMRI and local modeling, first streamlines and tractography algorithms and key steps in fields such as tractometry or connectomics.
Abstract: This talk discusses challenges in diffusion MRI tractography. How different factors such as scanners, streamline generation, and bundle segmentation methods play a role in final segmentation of white matter tracts.
Abstract: This talk discusses fMRI contrast (i.e., BOLD contrast) in white matter regions - challenges and potential applications. Real? Or artifact?
Vanderbilt Engineering News (2025)
Vanderbilt University Medical Center News (2023)