Microstructure
& Connectivity Lab

Research

Brain and spinal cord MRI

Acquisition, processing, biophysical modeling, and validation.

01 / Tractography

White matter pathways

We develop and validate diffusion MRI tractography to investigate white matter pathways and the organization of the living brain.

Related publications

Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc →Lifespan Trajectories of Asymmetry in White Matter Tracts →White matter micro- and macrostructure brain charts for the human lifespan →
Color-coded white matter pathways from the lab’s tractography research
Select the figure to view it at full size.
02 / Microstructure

Tissue microstructure

We connect MRI measurements with histology to study tissue organization in the brain and spinal cord.

Related publications

Standard Model Imaging in the Brain and Spinal Cord of MS Patients: Initial Assessment and Comparison to Diffusion Tensor Imaging →Lifespan Trajectories of Asymmetry in White Matter Tracts →White matter micro- and macrostructure brain charts for the human lifespan →

MRI and histology

We test what diffusion measurements can resolve about tissue.

Related work →
03 / Lifespan

White matter across the lifespan

We investigate how white matter develops and changes with age using diffusion MRI and longitudinal modeling.

Related publications

Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc →Charting Cervical Spinal Cord Morphometry Across the Lifespan →Lifespan Trajectories of Asymmetry in White Matter Tracts →
Projection tract illustration and age-related microstructural and macrostructural measurements
Select the figure to view it at full size.
04 / Open science

Software and validation

We share pipelines, quality assurance methods, datasets, and community challenges to support reproducible imaging research.

Related publications

Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc →Advancing high-resolution 7 T diffusion MRI: Evaluating phase-encoding correction strategies for distortion correction from basic to four-way acquisitions →Did you know? State-of-the-art preprocessing diffusion MRI data can improve tractography →

Methods and reproducibility

Software, quality assurance, benchmark datasets, and practical recommendations.

Related work →
05 / Spinal cord

Spinal cord MRI

We develop spinal cord acquisition and processing methods that address motion, distortion, and signal variability.

Related publications

Standard Model Imaging in the Brain and Spinal Cord of MS Patients: Initial Assessment and Comparison to Diffusion Tensor Imaging →Charting Cervical Spinal Cord Morphometry Across the Lifespan →Diffusion tractography outside the brain: the road less travelled →
Spinal cord MRI and tractography visualization from the lab’s research page
Select the figure to view it at full size.